Resveratrol Treats UVB-Induced Photoaging by Anti-MMP Expression, through Anti-Inflammatory, Antioxidant, and Antiapoptotic Properties, and Treats Photoaging by Upregulating VEGF-B Expression

Figure 7

Effect of VEGF-B on the photoprotective effect of RES. (a) Effect of transfected siRNA on the expression of mRNA of VEGF-B in Hacat cells (). (b) Effect of transfected siRNA on the expression of mRNA for GPX-4 in Hacat cells (). (c) Effect of transfected siRNA on the expression of mRNA for caspase3 in Hacat cells (). (d) Effect of transfected siRNA on the expression of mRNA for IL-6 in Hacat cells (). , compared to the control group; #, compared to the model group; &, &&&, compared to the NC group; (a)) , compared to the V group; (b)) , compared to the V + U group. C: control group; U: model group; R20, R40: RES concentration of 20 and 40 μM drug-administered groups. NC group: transfected siRNA NC, also negative transfection control group; NC + U group: transfected siRNA NC followed by UVB irradiation; V group: transfected siRNA VEGF-B; V + U group: transfected siRNA VEGF-B followed by UVB irradiation; V + R20 + U group: transfected siRNA VEGF-B followed by 20 μM RES drug-administration, 4 hours post-UVB irradiation.

(a)

(b)

(c)

(d)