Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease

Table 2

Role of flavonoids in Alzheimer’s disease.

S. no.	Flavonoids	Study model	Reported dose	Route of administration	Natural source	Outcome of the studies	Reference
1.	Epigallocatechin-3-gallate	APPswe/PS1dE9 mice	40 mg/kg	Oral	Green tea	Decreases Aβ plaques, neuroinflammation, increases memory and learning	[81]
2.	Cocoa flavonols	Human	550 mg, 994 mg	Oral	Dark chocolate	Improve cognitive function	[82]
3.	Apigenin, luteolin, kaempferol, quercetin	Human	2 gm to 20 gm	Oral	Parsley	Bioavailability, antioxidative, and biomarker	[83]; [84]
4.	Hesperidin, neohesperidin, naringenin, quercetin, rutin, etc.	Human	3-5 citrus per week	Oral	Citrus	Lower the risk of dementia	[85]
5	Flavanone	Human	Daily for 8 weeks	Oral	Orange	Cognitive benefits	[86]
6.	Combination of quercetin and dasatinib	Clinical trial in AD patients	—	Oral	Apple, honey, onion, citrus fruits	—	NCT04063124, NCT04785300, NCT04685590
7.	Epigallocatechin gallate	Clinical trial on AD patients	—	Oral	Tea, fruits, nuts		NCT03978052