A New Perspective on the Treatment of Alzheimer’s Disease and Sleep Deprivation-Related Consequences: Can Curcumin Help?

Table 3

Unpublished clinical studies with curcumin.

Study	Cohort	Intervention	Primary outcome	Main results
ClinicalTrials.gov, NCT01811381	80 participants with mild cognitive impairment (MCI)/subjective cognitive impairment	800 mg of curcumin (Longvida) in 4 capsules BID per day prior to meals, 12 months	Curcumin effects (first six-month period) or curcumin and aerobic yoga effects (second six-month period) on the changes in the levels of blood biomarkers for mild cognitive impairment relative to baseline or relative to placebo or nonaerobic yoga	Active, not recruiting
ClinicalTrials.gov, NCT03761381	20 participants with suspected dementia/AD	Oral curcumin supplement, 10 days	Curcumin will help improve protein detection with OCT and OCTA imaging taken twice, approximately 10 days apart	Recruiting
ClinicalTrials.gov, NCT04606420	100 participants with early AD	A low-fat (10–15%) whole-food vegan diet, high in complex carbs and low in refined carbs. Multivitamin, fish oil, curcumin, vitamin C, B12, CoQ10, lion’s mane, probiotic, and magnesium (40 weeks)	Change from Baseline in Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog), Clinical Global Impression of Change (CGIC), Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) scores	Recruiting
ClinicalTrials.gov, NCT01001637	26 participants with AD	Curcumin formulation (Longvida), 2000 mg or 3000 mg daily BID, 2 months	Not mentioned	Unknown status