Colchicine Ameliorates 5-Fluorouracil-Induced Cardiotoxicity in Rats

Table 5

Histopathological evaluation of heart in rats treated with COL.

Parameter	Experimental groups
	Control	5-FU	COL	COL+5-FU	value
Necrosis		^c,f		^a,d
Hyperemia		^c,f		^b,e,g

Values are expressed as (SD); for each treatment group. Asymptotic significance differences of heart lesions between treated groups were observed (; Kruskal–Wallis test). ^a–cStatistically significant differences between the control and other groups (^a, ^b, and ^c; Mann–Whitney test). ^d–fStatistically significant differences between the COL group and other groups (^d, ^e, and ^f; Mann–Whitney test). ^gStatistically significant differences between the 5-FU group and other groups (^g; Mann–Whitney test).