Hdac8 Inhibitor Alleviates Transverse Aortic Constriction-Induced Heart Failure in Mice by Downregulating Ace1

Figure 2

PCI34051 regulates renin-angiotensin system-related genes in the cardiac and pulmonary tissues of transverse aortic constriction (TAC) mice. (a–d) Cardiac and pulmonary mRNA levels of Ace1 and Ace2 in the sham+vehicle, sham+PCI34051 (10 mg/kg bodyweight/day), TAC+vehicle, and TAC+PCI34051 (3, 10, or 30 mg/kg bodyweight/day) groups (–6) were examined using quantitative real-time polymerase chain reaction (qRT-PCR). (e) Representative western blot images of Ace1 and Ace2 in cardiac tissues. (f, g) Quantification of Ace1 and Ace2 levels (–6). (h) Representative western blot images of Ace1 and Ace2 in the pulmonary tissues. (i, j) Quantification of Ace1 and Ace2 levels (–6). (k–n) Cardiac and pulmonary mRNA levels of Agtr1 and Agtr2 were determined using qRT-PCR and normalized to those of Gapdh (–6).

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