Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

Figure 6

PFC metabolic analysis (/group). (a) The PCA scatter plot of PFC samples among the control, DSS. and DSS + CUR group. (b, c) The PLS-DA score plots and validation plot of PFC samples obtained from the DSS vs. control group. (d, e) The PLS-DA score plots and validation plot of PFC samples obtained from DSS + CUR vs. DSS group. (f) PFC KEGG enrichment scatter plot of DSS vs. control group. (g) PFC KEGG enrichment scatter plot of DSS + CUR vs. DSS group. (h) Venn diagrams showed the differential metabolites. Differential metabolites were identified based on and as the filter of DSS vs. control group and DSS + CUR vs. DSS group. (i) Heatmap of the relative abundances of differential metabolites among three groups. The red or blue color represents the high relative or low relative of abundance in each sample. (j) The change of the key PFC metabolites for the efficacy of curcumin.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)