Propofol via Antioxidant Property Attenuated Hypoxia-Mediated Mitochondrial Dynamic Imbalance and Malfunction in Primary Rat Hippocampal Neurons

Figure 3

Hypoxia-induced intracellular oxidative stress and mitochondrial abnormality was mitigated by propofol, α-tocopherol, or ebselen. Data were presented as the percentage of of treated neurons compared with that of untreated control neurons, which was set as 100%, and represents the number of independent repeats. (a) Hypoxia induced intracellular ROS accumulation, which was attenuated by propofol, α-tocopherol, and ebselen. (b) Hypoxia induced intracellular superoxide anion generation, which was attenuated by propofol, α-tocopherol, and ebselen. (c) Hypoxia-induced effect on mitochondrial dynamic balance was attenuated by propofol, α-tocopherol, and ebselen. (d) Hypoxia-induced effect on mPTP opening was attenuated by propofol, α-tocopherol, and ebselen. (e) Hypoxia-induced effect on MMP value was attenuated by propofol, α-tocopherol, and ebselen. (f) Hypoxia-induced effect on intracellular ATP content was attenuated by propofol, α-tocopherol, and ebselen.

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