A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation

<div>Preliminary and synthesis of a linarin derivative 4<span class="nowrap"><svg height="7.86364pt" id="M12" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>-</span>benzylapigenin-7 -<i>β</i>-rutinoside (BLR). (a) The names and structures of linarin and its derivates and (b) the synthetic route and chemical structure of BLR from linarin. The neuroprotective effects of linarin and its derivatives were evaluated by the mouse MCAO model, and the result of preliminary study was not shown.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation 

Figure 1 | A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation 