A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation

Figure 6

Effects of BLR on the vasculature and angiogenesis pathway-related gene expression by RNA sequencing analysis. (a) Scatter plot showed the differences of gene expression between MCAO group and BLR group. Red dots represented as upregulated genes, blue dots represented as downregulated genes, and gray dots indicated no change. (b) Pathway enrichment analyses were performed on the clusterProfiler software using ClueGO module at 0.05 significant level. (c) Interaction network and cluster relationship of differentially expressed genes involved in MCAO mice treated with BLR or saline were shown. (d) Heatmap revealing RNA sequencing result of upregulation and downregulation of vasculature and angiogenesis pathway-related gene expression between MCAO group and BLR group ( per group). Red blocks indicated high expression, and blue blocks indicated low expression.

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