[Retracted] Mild Hypothermia Promotes Ischemic Tolerance and Survival of Neural Stem Cell Grafts by Enhancing Global SUMOylation

Figure 6

Mild hypothermia increased the survival of NSCs transplanted into the ischemic penumbra of rats and improved neuromotor function.(a) Representative TTC-stained coronal brain sections of sham-operated (Sham) rats, MCAO rats, MCAO rats transplanted with NSCs (MCAO+NSC), and MCAO rats transplanted with NSCs kept at 32–34°C for 12 h (MCAO+NSC 33°C). Immunofluorescence staining of cerebral cortex tissue sections (scale bar, 20 μm). (b) Quantification of percentages of cerebral infarct volume () and proportions of nestin-positive to DAPI-positive cells (); data are expressed as . (c) Rotarod testing was used to analyze the neurological deficits of rats in each group. (d) Spontaneous activity in the open field over30 min and (e) time spent in corners. (f)–(h) Escape latency to find the nonvisible platform. Number of crosses in the probe test and time spent in quadrant IV. Data shown indicate (). and vs. Sham, ^# and ^## vs. MCAO.

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