miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2

<div>HO-1/BMMSCs attenuate histopathological injury and hepatocyte death and suppress the activation of the innate immune response in steatotic liver IRI. (a) Pathological HE staining of steatotic liver IRI with BM or HBM treatment. (b) TUNEL staining of steatotic liver IRI with BM or HBM treatment. (c) Serum ALT and AST levels in IRI with BM or HBM treatment. (d) IL-6, TNF-<i>α</i>, and IL-1<i>β</i> levels detected using ELISA. Representative images of CD68 (e) and MPO (f) immunohistochemical staining. (g) HMGB1/TLR4/p-p65 protein levels assessed using western blotting. (h) Semiquantitative analysis of (g). 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2 

Figure 2 | miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2 