miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via Iron Responsive Element Binding Protein 2

Figure 9

Summary schematic diagram of the mechanisms underlying HO-1/BMMSC-induced ferroptosis modulation to alleviate SHP-HR injury. miR-29a-3p, which targets IREB2, is abundant in HO-1/BMMSC-exosomes and could decrease the IREB2 protein level. The reduced IREB2 level led to an increase in the level of FTH1 and decreased the level of TFR1 through posttranscriptional regulation, which ultimately reduced the level of intracellular Fe²⁺ and the production of lipid ROS and inhibited the occurrence of ferroptosis in SHP-HR. BMMSCs: bone marrow mesenchymal stem cells; HO-1: heme oxygenase 1; HR: hypoxia reoxygenation; SHPs: steatotic hepatocytes.