The Role of CD147 in Pathological Cardiac Hypertrophy Is Regulated by Glycosylation

Figure 2

Comparisons of survival rates and cardiac functions among vehicle, CD147-OE, and CD147-mutant mice after transverse aortic constriction (TAC). (a) Schematic illustration of the study. Mice were intramyocardially injected with viral genomes/mL of AAV-9 vector 14 days before TAC. Hearts from each group were analysed at 8 weeks after TAC. (b) Evaluation of transverse aortic peak velocities by echocardiographic examination ( mice/group). Upper panel, representative ultrasonic picture; lower panel, quantitative results. (c) Survival rates 8 weeks after TAC surgery for each group. (d) Echocardiographic analysis of cardiac dysfunction and remodeling. The representative M-mode images of the papillary muscles and maximal mitral valve Doppler flow profiles in the apical 4-chamber view are shown in the left panel. Statistical analysis of the echocardiographic parameters is shown in the right panel ( mice/group). vs. the sham group; vs. the sham group; vs. the sham group; vs. the sham group; ^# vs. the vehicle group; ^## vs. the vehicle group; ^✟ vs. the OE group; ^✟✟ vs. the OE group. The data are expressed as the . E/A: transmitral filling peak velocity/atrial wave velocity; EF: ejection fraction; FS: fractional shortening; LV mass: left ventricular mass; LVIDs: left ventricular internal diameter during the systolic phase; LVIDd: left ventricular internal diameter during the diastolic phase; LVVs: left ventricular end-systolic volume; LVVd: left ventricular end-diastolic volume.

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