Occludin Promotes Adhesion of CD8⁺ T Cells and Melanocytes in Vitiligo via the HIF-1α Signaling Pathway

Figure 2

(a, b) The protein expression level of OCLN in normal control group and CD8⁺ T cells transfected with OCLN overexpression plasmid (, , C: control; O: OCLN-OE). (c) The mRNA expression level of OCLN in vitiligo CD8⁺ T cells and vitiligo CD8⁺ T cells transfected with OCLN siRNA (, ). (d) The expression level of OCLN in normal K562 cells and HaCaT cells. (e) The adhesion rate of melanocytes and normal K562 cells or K562 cells transfected with OCLN overexpression plasmid. (f) The adhesion rate of CD8⁺ T cells to melanocytes (, , , ). The red mark represents Melan-A-positive staining, the green mark represents CD8-positive staining, and the blue mark represents DAPI. (g, h) The apoptosis of melanocytes after coculture with CD8⁺ T cells (, ).

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