Research Article
Small Noncoding RNAs Contribute to Sperm Oxidative Stress-Induced Programming of Behavioral and Metabolic Phenotypes in Offspring
Figure 2
Behavior, blood corticosterone, and hippocampal GR in male offspring generated from sperm 29-34 nt RNA injection. (a) Illustration of zygotic injection of sperm 29-34 nt RNAs to generate F1 male offspring. (b) Forced swimming test. (c) Latency to first immobility of forced swimming test. (d) Open field test. (e) Light-dark box test. (f) Blood concentration of corticosterone detected by ELISA. In (b–f), mice per group. (g) The relative expression level of GR mRNA in hippocampus detected by RT-PCR. mice per group. All data are plotted as . Each dot represents one mouse.
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |
(g) |