Oxidative Medicine and Cellular Longevity

Review Article

The Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Knee Osteoarthritis: An Updated Systematic Review and Meta-Analysis of 56 Randomized Controlled Trials

Table 2

Assessment of study quality and risk of bias.
Study7-item criteria
ABCDEFGTotal
Chen 2017 [28]?–?++++4
Chen 2018 [29]+?+++++6
Cui 2017 [31]+?+?+++5
Cui 2018 [30]??+++++5
Dou 2015 [32]+++++++7
Fu 2018 [33]+–+?+++5
Guo 2019 [34]++––+++5
He 2019 [35]??+++–+4
Hong 2013 [36]??+++++5
Hu 2012 [37]??+++++5
Huang 2015 [38]?–+–+++4
Jiang 2009 [39]??++++?4
Li 2018 [40]?––++++4
Liu 2011 [43]??++++–4
Liu 2016 [41]??+++++5
Liu 2017 [42]?++++++6
Lu 2016 [44]???++++4
Luo 2019 [45]+?+–+–+4
Ma 2009 [48]??++?++4
Ma 2018 [46]++––+++5
Ma 2019 [47]+?+++++6
Mo 2018 [49]+?+?+++5
Pan 2017 [22]+–+–+++5
Qian 2019 [51]+–+++++6
Ren 2016 [53]?++++–+5
Ren 2018 [52]+?––+++4
Rong 2017 [54]?+––+++4
Shi 2019 [55]+–+++++6
Song 2017 [56]+–+++++6
Sun 2018 [57]+–+++++6
Tan 2014 [58]??+–+++4
Tang 2012 [59]+?+?+++5
Wang 2013 [60]??+++?+4
Wang 2019 [61]+–?++++5
Wen 2016 [62]+–+++++6
Wu 2012 [65]+++++++7
Wu 2018 [63]+–––+++4
Wu 2018 [64]+?+?+++5
Xia 2017 [66]??–++++4
Yang 2016 [67]??–++++4
Yang 2019 [68]+?+–+++5
Yao 2013 [69]+?+++++6
Yi 2017 [70]+–+++++6
Yi 2017 [71]??+–+++4
Yu 2010 [72]?–++++–4
Yuan 2017 [73]+?+?+++5
Zhang 2016 [74]??+–+++4
Zhang 2017 [77]?–+++++5
Zhang 2018 [76]+–?–+++4
Zhang 2019 [75]++––+–+4
Zheng 2014 [78]??+++–+4
Zheng 2019 [79]+++++++7
Zhong 2017 [80]+?+++++6
Zhou 2012 [81]?–+++++5
Zhu 2013 [82]+–+++++6
Zhuo 2019 [83]?–?++++4
A to G, the 7-item criteria. A: random sequence generation; B: allocation concealment; C: blinding of participants and personnel; D: blinding of outcome assessment; E: incomplete outcome data; F: selective reporting; G: other bias; +: low risk of bias, –: high risk of bias; ?: uncertain risk of bias.