Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10

Figure 4

Anisomycin-induced phosphorylation of H3S10 was associated with transcriptional activation of ferroptosis-related genes. (a) Representative graphs of chromatin immunoprecipitation- (ChIP-) sequencing results. (b) Gene Ontology (GO) analyses of differentially enriched genes. BP: biological processes; CC: cell components; MF: molecular functions. (c) Kyoto Encyclopedia of Genes and Genomes (KEGG) results ranked by degree of enrichment. (d) Protein-protein interactions of ferroptosis-related genes enriched in the term of ferroptosis in (c) (NCOA4, SLC3A2, LPCAT3, PRNP, FTL, FTH1, SLC40A1, GCLC, and GPX4).

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