[Retracted] Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats
Table 7
Effect of MPHE, hesperidin, and quercetin on histopathological scores of livers of NAPAP-administered rats.
Histopathological changes
Score
Normal control
NAPAP
NAPAP+MPHE
NAPAP+hesperidin
NAPAP+quercetin
Inflammation
0
6 (100%)
—
2 (33.3%)
4 (66.7)
4 (66.7)
I
—
1 (16.7%)
2 (33.3%)
2 (33.3%)
1 (16.7%)
II
—
3 (50%)
2 (33.3%)
—
1 (16.7%)
III
—
2 (33.3%)
—
—
—
Necrosis
0
6 (100%)
—
5 (83.3%)
2 (33.3%)
4 (66.7)
I
—
1 (16.7%)
1 (16.7%)
2 (33.3%)
2 (33.3%)
II
—
2 (33.3%)
—
1 (16.7%)
—
III
—
3 (50%)
—
1 (16.7%)
—
Activated apoptosis
0
6 (100%)
—
3 (50%)
2 (33.3%)
5 (83.3%)
I
—
1 (16.7%)
3 (50%)
4 (66.7)
1 (16.7%)
II
—
4 (66.7)
—
—
—
III
—
1 (16.7%)
—
—
—
Vacuolar degeneration
0
6 (100%)
—
2 (33.3%)
—
—
I
—
1 (16.7%)
1 (16.7%)
1 (16.7%)
3 (50%)
II
—
—
—
2 (33.3%)
3 (50%)
III
—
5 (83.3%)
3 (50%)
3 (50%)
—
Vascular congestion
0
6 (100%)
—
3 (50%)
2 (33.3%)
4 (66.7%)
I
—
2 (33.3%)
3 (50%)
3 (50%)
2 (33.3%)
II
—
2 (33.3%)
—
1 (16.7%)
—
III
—
2 (33.3%)
—
—
—
Stimulated Kupffer cell proliferation
0
6 (100%)
—
3 (15.0%)
1 (16.7%)
3 (15.0%)
I
—
—
1 (16.7%)
2 (33.3%)
3 (15.0%)
II
—
2 (33.3%)
2 (33.3%)
2 (33.3%)
—
III
—
4 (66.7%)
—
1 (16.7%)
—
0: null; I: mild; II: moderate; III: severe lesions. The number of animals in each group is 6. The % in parentheses is the percent of animals in each grade of lesion.
