[Retracted] Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats
Table 8
Effect of MPHE, hesperidin, and quercetin on histopathological scores of the kidneys of NAPAP-administered rats.
Histopathological changes
Score
Normal control
NAPAP
NAPAP+MPHE
NAPAP+hesperidin
NAPAP+quercetin
Inflammation
0
6 (100%)
—
5 (83.3%)
4 (66.7)
5 (83.3%)
I
—
1 (16.7%)
1 (16.7%)
1 (16.7%)
1 (16.7%)
II
—
2 (33.3%)
—
1 (16.7%)
—
III
—
3 (50%)
—
—
—
Necrosis
0
6 (100%)
—
6 (100%)
5 (83.3%)
6 (100%)
I
—
1 (16.7%)
—
1 (16.7%)
—
II
—
1 (16.7%)
—
—
—
III
—
4 (66.7)
—
—
—
Activated apoptosis
0
6 (100%)
1 (16.7%)
6 (100%)
5 (83.3%)
6 (100%)
I
—
5 (83.3%)
—
1 (16.7%)
—
II
—
—
—
—
—
III
—
—
—
—
—
Congestion of renal blood vessels
0
6 (100%)
—
6 (100%)
4 (66.7%)
4 (66.7%)
I
—
—
—
2 (33.3%)
2 (33.3%)
II
—
2 (33.3%)
—
—
—
III
—
4 (66.7)
—
—
—
0: null; I: mild; II: moderate; III: severe lesions. The number of examined sections in each group is six. The % in parentheses is the percent of animals in each grade of lesion.
