Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential

Figure 1

Illustration of compounds of tacrine analogues. The compound number denoted by (1) 9-Amino-2,3-dihydro-1H-cyclopenta[1,2-b]quinoline. (2) 11-Amino-2,3,4,5-tetrahydro-1H-cyclohepta[1,2-b]quinoline. (3) 12-Amino-1,2,3,4,5,6-hexahydrocycloocta[1,2-b]quinoline. (4) 9-Amino-1,4-methano-1,2,3,4-tetrahydroacridine. (5) 9-Amino-1,4-methano-1,2,3,4-tetrahydro-4,11,11-trimethylacridine. (6) 6-Amino-4,5-benzo-5H-cyclopenta[1,2-b]quinoline. (7) 9-Amino-5,6,7,8-tetrahydroquinolino[3,2-e]-1-benzazocine. (8) Ethyl 4-(1-acetyl-1H-pyrrol-2-yl)-5-amino-6,7,8,9- tetrahydro-2-methyl-4H-pyran[2,3-b]quinoline-3-carboxylate. (9) Ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-(4- pyridyl)-benzo[b][1–8]naphthyridine-3-carboxylate. (10) 9-amino-6-chloro-2,3-dihydro-[1H] cyclopenta [1,2-b]-quinoline. (11) 5-Amino-2-(dimethylamino)-6,7,8,9-tetrahydrobenzo[1,8-b]-naphthyridine-3-carbonitrile. (12) 5-Amino-2-(prop-2-yn-1-ylamino)-6,7,8,9-tetrahydrobenzo[1,8-b]-naphthyridine-3-carbonitrile. (13) 5-Amino-2-(methyloxy)-6,7,8,9-tetrahydrobenzo[1,8-b]-naphthyridine-3-carbonitrile. (14) 5-Amino-2-chloro-6,7,8,9-tetrahydrobenzo[1,8-b]- naphthyridine-3-carbonitrile. (15) 5-Amino-7-benzyl-2-methoxy-6,7,8,9- tetrahydropyrido[2,3-b][1,6]naphthyridine-3-carbonitrile. (16) 5-Amino-7-benzyl-2-chloro-6,7,8,9- tetrahydropyrido[2,3-b][1,6]naphthyridin-3-carbonitrile. (17) Bis(7)tacrine dimer. (18) Cystamine-tacrine dimer. (19) Nontoxic tacrine-organic nitrates, compound E (as the name wasn’t found in the paper). (20) N-(7-Oxo-7H-dibenzo[de,h]quinolin-9-yl)-3-((2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)amino)propanamide. (21) N1-(2-(Dimethylamino)benzyl)-N9-(1,2,3,4-tetrahydroacridin-9-yl)nonane-1,9-diamine. (22) N-alkyl-7-methoxytacrine.