The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion

Figure 1

Combination of Rho and MMF prolongs cardiac allograft survival. Hearts from BALB/c donors were transplanted to C57BL/6 mice that were treated with Rho and combination of Rho and low dose of MMF after the operation 5 days. Cardiac allograft rejection was observed based on the cessation of palpable cardiac contraction ( mice per group). (a) Chemical structure of Rho. (b) The survival time of the cardiac grafts. In the combined treatment group, the mean survival time of the grafts was significantly longer ( days) than those of the control group ( days) (). (c) Hematoxylin-eosin (HE) staining on the cardiac allografts from control, MMF group, Rho-treated, and combination of Rho and low dose of MMF group. (d) The infiltration of CD4⁺ T cells and CD8⁺ T cells in transplanted hearts. (e) The immunofluorescence staining of TUNEL in allografts.

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