The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion

Figure 4

Rho and combination treatment interfere with DCs maturation after allotransplantation. Splenocytes and LN cells were collected from recipient mice or naïve mice and analyzed for the markers of DC maturation 5 d after heart allotransplantation. (a–d) The percentage of CD86⁺ MHC II⁺ CD80⁺ DCs within CD11c⁺ population was determined via the FACS analysis. Data of histograms are presented as from six independent experiments (, , mice per group versus the control group). (e–h) The quantitative analysis of percentage of CD86⁺, MHC II⁺, and CD80⁺ DCs within CD11c⁺ population in spleens and draining lymph nodes by GraphPad Prism 8.0. Data of histograms are presented as from six independent experiments (, , mice per group versus the control group).