Epigallocatechin Gallate Relieved PM2.5-Induced Lung Fibrosis by Inhibiting Oxidative Damage and Epithelial-Mesenchymal Transition through AKT/mTOR Pathway

Figure 7

The possible mechanisms by which EG relieves PM2.5-induced lung fibrosis. PM2.5 could increase the phosphorylation of AKT, which subsequently phosphorylated mTOR in lung epithelial cell. The activated AKT/mTOR pathway further gave rise to oxidative damage and EMT, eventually causing lung fibrosis. The natural epigallocatechin gallate extracted from green tea could block the activation of AKT/mTOR, thus improving PM2.5-induced lung fibrosis by decreasing oxidative damage and EMT.