Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury

Figure 1

Pretreatment fucoxanthin decreased BUN and Cr levels, attenuated pathological injury, and reduced KIM-1 expression in mice after renal I/R. The I/R model was established with 45 minutes of ischemia and 24 hours of reperfusion. The doses administered in the fucoxanthin treatment groups were 25 mg/kg, 50 mg/kg, and 100 mg/kg. (a) Schematic diagram of the experiment process. (b) Serum BUN levels. (c) Serum Cr levels. (d) and (f) Representative images of kidney HE staining (magnification ×400; ) and its quantitative analysis. (e) and (g) Representative images of KIM-1 immunohistochemical staining (magnification ×400; ) and its quantitative analysis. Values are expressed as , . ^# compared with Sham group, and compared with group.

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