<i>α</i>-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats

<div>Effect of ALA supplementation on brain mRNA expression of cytokines (<i>TNF-α</i>) and apoptotic proteins (<i>Casp-3</i>). 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499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> C: control animals not supplemented with ALA; <i>Casp-3</i>: caspase 3; HFD: high-fat diet-fed animals not supplemented with ALA; HFD+ALA: high-fat diet-fed animals supplemented with ALA; <i>TNF</i>-<i>α</i>: tumor necrosis factor-alpha.</div>

Oxidative Medicine and Cellular Longevity

fig10

Figure 10

Figure 10: <i>α</i>-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats 

Figure 10 | α-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats 