Research Article

miR-154-5p Affects the TGFβ1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1

Figure 5

Indirect verification of the miR-154-5p target gene. Smurf1 in diabetic rats (a) and RMCs (b) cultured with high glucose. Smurf1 in RMCs with high glucose, miR-154-5p inhibitor, Smurf1 siRNA, and TGFβ1/Smads pathway inhibitor (c). NC: normal control; DN: diabetic nephropathy; NG: normal glucose; HM: high mannitol; HG: high glucose. vs. NC or NG, ; #vs HG, . samples/group.