Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK

Figure 3

Dex relieved MPTP-induced motor dysfunction in mice and increased the expression of TH-positive neurons. (a, b) Exercise distance in 5 min. (c) T-turn time in the pole test. (d) T-total time in the pole test. (e) Latency to fall. (f) Representative immunofluorescence images. (g) The statistical results of TH fluorescence intensity in the SNpc area of each group. (h) Relative expression of TH in SN of mice was studied using the western blot technique. (i) Densitometry analysis of proteins. Values are represented in the form of . (). , , and , ns: not significant.

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