Dysregulation of EZH2/miR-138-5p Axis Contributes to Radiosensitivity in Hepatocellular Carcinoma Cell by Downregulating Hypoxia-Inducible Factor 1 Alpha (HIF-1α)

Figure 1

Expression of EZH2, miR-138-5p in subgroups of liver cancer patients with different prognoses and validation in vitro. (a) The plot shows EZH2 mRNA expression level between HCC specimens and liver tissue. (b) The plot shows EZH2 mRNA expression level in grades 1-4 HCC patients. (c) EZH2 expression was correlated with poorer OS in the HCC cohort of the Kaplan Meier plotter database. (d) The plot shows miR-138-5p expression level between HCC specimens and liver tissue. (e) The plot shows miR-138-5p expression levels in grades 1-4 HCC patients. (f) The level of miR-138-5p expression was correlated with poorer OS in the HCC cohort of the Kaplan Meier plotter database. (g) EZH2 mRNA expression was measured in five HCC cells (HepG2, Hep3B, Huh-7, PLC/PRF/5, and SMMC-7721) and immortalized human liver cell line L-02. (h) EZH2 protein expression was measured in five HCC cells (HepG2, Hep3B, Huh-7, PLC/PRF/5, and SMMC-7721) and immortalized human liver L-02 cell line. (i) Level of miR-138-5p expression was tested in five HCC cells (HepG2, Hep3B, Huh-7, PLC/PRF/5, and SMMC-7721) and immortalized human liver cell line L-02. , (compared to L-02).

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