Poststroke Seizure and Epilepsy: A Review of Incidence, Risk Factors, Diagnosis, Pathophysiology, and Pharmacological Therapies

Figure 4

Shows the differing mechanisms of action by which various statins exude their potential antiepileptogenic effects. Atorvastatin and rosuvastatin upregulate nitric oxide synthase (NOS), while lovastatin decreases inflammatory cytokines. Simvastatin inhibits Caspase-3 and upregulates Bcl-2, thus inhibiting neuronal apoptosis.