Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Table 1

Neuroprotective agent in intensive care for hemorrhagic stroke, acute ischemic stroke, and brain trauma management.

Neuroprotective agents	Class	Therapeutic applications	Recommended dosage	Witness the people	Result	References
Polyarginine R18; NA-1 (TAT-NR2B9c)	Glutamate blockers	Ischemic stroke	1000 nmol/kg	Rat	Maintained functional outcomes as well as reduced infarct volume.	[67–71]
Magnesium sulfate	Glutamate blockers/NMDA channels blocker	Hemorrhagic and ischemic stroke, traumatic brain injuries	Up to 65 mmol/day	Patients were indeed human beings.	One explanation Mgso4 had such a successful aspect was the fact that it reduced late-onset ischemia of the central nervous system (DCI)	[60, 72–78]
Rosuvastatin and simvastatin atorvastatin, mevastatin	Statins	Ischemic stroke	Up to 20 mg/kg/day	Mice and humans are the subjects of this investigation	a decrease in mortality, a decrease in the size of something like the infarct, and an increase in cerebral blood flow	[61–63, 65]
Melatonin	Hormone	Hemorrhagic and ischemic stroke, traumatic brain injuries	Up to 200 mg/kg/day	Mice and rats from New Zealand’s white rabbit electorate	Reduce oxidative damage by attempting to prevent endothelial cell vasospasm and apoptosis	[66, 79]
Erythropoietin	Growth factor for determining the ability	Stroke, both hemorrhagic and ischemic, and traumatic injury toward the brain	Up to 5000 units/kg	Rabbit, rat, mice	a smaller infarct, less vasospasm, and an effective therapy in terms of function	[80, 81]
Cyclosporin A (CsA) and FK506 (tacrolimus)	Immunosuppressant	Strokes, brain trauma, ischemic stroke	As much as 10 milligrams per kilogram for CsA; FK506 has a full dose of 6 milligrams per kilogram	Rat	Improved functional recovery, significantly reduced volume of infarct tissue	[82, 83]