Quercetin Protects against MPP⁺/MPTP-Induced Dopaminergic Neuron Death in Parkinson’s Disease by Inhibiting Ferroptosis

Figure 8

Schematic hypothesis of the antiferroptosis effect of QCT in Parkinson’s disease. MPP⁺- and MPTP-induced ferroptosis is involved in midbrain dopaminergic neuronal death. QCT positively regulated SLC7A11 and GPX4 protein levels by activating the Nrf2 pathway. Furthermore, QCT alleviates mitochondrial dysfunction and decreases mitochondrial ROS generation, which is a core factor for ferroptosis.