Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1<i>α</i> Axis

<div>Hypoxia enhanced resistance of glioma cells to SAS-induced ferroptosis. (a) Cell viability curves at different concentrations of SAS for 24 h. Glioma cells under hypoxic environment became less sensitive to SAS. (b) Half-maximal inhibitory concentrations (IC<sub>50</sub>) were calculated in each group. Hypoxic cells had an obvious higher IC<sub>50</sub> to SAS. (c) Lipid peroxidation assessed in the U87 and U251 cells after exposure to hypoxia, SAS, and Fer-1 by flow cytometry using C11-BODIPY. (d) Clone formation assay of cancer cells in the absence or presence of SAS or Fer-1 under normoxia or hypoxia. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1<i>α</i> Axis 

Oxidative Medicine and Cellular Longevity

Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1α Axis

Figure 1