Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1α Axis

Figure 7

Pattern diagram of hypoxia modulation of ferroptosis. Hypoxia activated PI3K/AKT/HIF-1α pathway to increase SLC7A11 expression in the U87 and U251 cells. SLC7A11 protein neutralized lipid peroxidation to defend SAS-induced ferroptosis.