Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Figure 7

Summary of the study. Resveratrol sufficiently suppressed the age-related inflammatory pathways including the expression of TNF-α, NFκB, and the activity of MPO while intensified the endogenous antioxidant defenses through the induction of GSH and HO system. Presumably, as a result of these processes, the necrotic extension of the heart was also significantly reduced. HO: Heme oxygenase; GSH+GGSG: Total glutathione; ROS: Reactive oxygen species; NFκB: Nuclear factor kappa B; TNF-α: Tumor necrosis factor alpha; MPO: Myeloperoxidase enzyme.