Ginkgolic acid improves bleomycin-induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation

Figure 2

Ginkgolic acid (GA) regulated the expression of key proteins in the SUMOylation pathway in vivo. Mice were challenged with bleomycin (BLM) through the airway, and GA was administered through intraperitoneal injection 24 h later. Meanwhile, the control group was administered and treated with normal saline (). (a) Images of representative HE and Masson staining of lung tissues from mice in the indicated groups. Quantitative lung injury scores and Ashcroft scores are shown as box charts. Scale bar: 100 μm. (b) SUMO1, UBC9, and SENP1 protein levels were detected by IHC and WB. Data are presented as the . , .

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