Clinical Relevance and Tumor Growth Suppression of Mitochondrial ROS Regulators along NADH:Ubiquinone Oxidoreductase Subunit B3 in Thyroid Cancer

Figure 3

The mitoROS and clinicopathological relevance of NDUFB3 expression in thyroid tumors. (a) The expression distribution of NDUFB3 gene in the three indicated clusters based on mitoROS regulator-dependent consensus clustering. Each data point in a dot plot represents a single patient. Box plots depict the median (horizontal line in each box), the 25th percentile (bottom of each box), and the 75th percentile (top of each box). NDUFB3 gene expression was analyzed for significance using the unpaired Student -test. (b) Representative flow cytometry analysis of NDUFB3 shRNA and control shRNA showing respective mitoROS levels in BCPAP and C643 cells. (c) Relationship between NDUFB3 expression and clinicopathological variables and in patients with thyroid cancer. The unpaired -test was used to analyze statistical assessments. The association between NDUFB3 expression and clinical characteristic variables was analyzed using the Pearson chi-squared test or Fisher’s exact test.

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