Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis

<div>TRF reverses the overexpression of the circadian gene Per2 in NASH mice. (a) Hepatic mRNA levels for Bmal1, Clock, Per2, Per1, and Rev-Erb<i>α</i> were measured by RT-qPCR with GAPDH used as a control. (b) The Per2 protein level was measured by western blotting, and GAPDH was used as a control. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis 