Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer’s Disease

<div>Overexpression of TRPML1 protects axons by interacting with p62 in APP/PS1 transgenic mice. (a) Protein expression of BDNF and the ratio of p-TrkB/TrkB and p-CREB/CREB in hippocampal tissues of mice evaluated by Western blot analysis. (b) Dendrites and dendritic spines in hippocampal tissues of mice evaluated by Golgi-Cox staining. (c) Cell apoptosis in hippocampal tissues of mice, tested by TUNEL assay. (d) Senile plaques in hippocampal tissues of mice, evaluated by Congo red staining. 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vs. C57BL/6J WT mice; <sup>#</sup><svg height="11.7782pt" id="M57" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 44.5261 11.7782" width="44.5261pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer’s Disease 