Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer’s Disease

Figure 7

A schematic diagram illustrating the NAD regulatory mechanism of TRPML1 in AD. TRPML1 promotes the autophagosome-lysosome fusion through recruitment of dynein by interacting with p62 and stimulates the nuclear translocation of BDNF, ultimately attenuating the NAD in AD.