The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury

<div>AK046375 decreased the H<sub>2</sub>O<sub>2</sub>-induced apoptosis on primary cortical neurons and astrocytes. (1) BCL2, Bax, and cleaved-caspase-3 in neurons (a) and astrocytes (d) detected by western blotting and quantification. (2) Cytochrome C (Cytc) in cytoplasm and mitochondria in neurons (b) and astrocytes (e) and quantification (VDAC1 was used as a loading control for mitochondrial proteins.). 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury 

Figure 4 | The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury 