The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury

Figure 7

AK046375 maintains BBB integrity and decreases brain water content in mice on 7 days after TBI. (a) Western blotting results of ZO1, occludin, and claudin-5 in each group and quantification (/group, ). (b) Brain water content in each group after TBI (/group, ). (c, d) Fluorescence of Evans blue and Evans blue extravasation in each group around the injury site (/group, ) ( μm, 200x) ( vs. the overexpression vector group, ^& vs. the knockdown vector group by one-way ANOVA).

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