The lncRNA-AK046375 Upregulates Metallothionein-2 by Sequestering miR-491-5p to Relieve the Brain Oxidative Stress Burden after Traumatic Brain Injury

Figure 8

AK046375 improves motor function, learning ability, and spatial memory in mice after TBI. (a) NSS scores were detected on preoperative, 1, 3, 7, and 14 days after TBI. (b) Wire-gripping scores in each group on preoperative, 1, 3, 7, and 14 days after TBI. (c) The duration of rotarod test in each group on preoperative, 1, 3, 7, and 14 days after TBI. (d) Latency spent in quadrant 4 in cued learning performance in the Morris Water Maze (MWM) test on 15 to 19 days after TBI. (e) Swimming tracks in MWM test on 20 days after TBI. (f) Length of the swimming tracks in quadrant 4 on 20 days after TBI. (g) Time in quadrant 4 in MWM test on 20 days after TBI. (h) Times traveling across the platform in MWM test on 20 days after TBI. (i) Swimming speed in MWM test on 20 days after TBI (/group, ) ( vs. the overexpression vector group, ^& vs. the knockdown vector group by two-way ANOVA test for NSS scores, wire-gripping scores, rotarod test, and latency spent in quadrant 4. One-way ANOVA for length of the swimming tracks in quadrant 4, time in quadrant 4, and the number of times the mice crossed over the original location of the platform on 20 days after TBI).

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