[Retracted] Exosomal miR-27b-3p Derived from Hypoxic Cardiac Microvascular Endothelial Cells Alleviates Rat Myocardial Ischemia/Reperfusion Injury through Inhibiting Oxidative Stress-Induced Pyroptosis via Foxo1/GSDMD Signaling

Figure 7

The supposed schematic diagram of miR-27b-3p-Foxo1 mediated pyroptosis mechanism in I/R injury. Foxo1 expression on one hand induces GSDMD-mediated pyroptosis by activating the histone acetylation of GSDMD and, on the other hand, promotes NLRP3/caspase-1-mediated pyroptosis. Hypoxic CMECs-derived exosomes carrying high level of miR-27b-3p counteracted these interactions.