Interleukin 10 Attenuates Angiotensin II-Induced Aortic Remodelling by Inhibiting Oxidative Stress-Induced Activation of the Vascular p38 and NF-κB Pathways

Figure 3

Effect of IL-10 on the expression of vascular fibrosis-associated genes. (a)–(d) The mRNA levels of fibrotic markers in the aorta, including Col1a1, CTGF, TGF-β, and Col3a1, were assessed by qPCR ( =6 for each group). (e)–(h) The protein expression levels of fibrotic markers in aortas from IL-10 group and control group mice infused with Ang II or saline were examined by western blotting. Relative protein levels were normalized to GAPDH ( = 3 for each group). (a)–(h) The data are representative of three independent experiments. Error bars show S.E. , , .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)