Research Article
Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway
Figure 4
Liensinine regulated the expressions of factors related to apoptosis, cycle arrest, and JAK2/STAT3 pathway activation in osteosarcoma cells. (a, b) The expressions of factors related to apoptosis (Bcl-2, Bax, cleaved caspase 3, and cleaved PARP1), cycle arrest (Cyclin D1), and JAK2/STAT3 pathway activation (p-STAT3, STAT3, p-JAK2, and JAK2) in SaOS-2 cells after being treated with liensinine were detected by Western blotting. (c, d) The expressions of factors related to apoptosis, cycle arrest, and JAK2/STAT3 pathway activation in 143B cells after being treated with liensinine were detected by Western blotting. in each group. , , and vs. 0 μM.
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