Comprehensive Network Analysis Reveals the Targets and Potential Multitarget Drugs of Type 2 Diabetes Mellitus

Figure 2

Analysis of important genes related to diabetes mellitus and insulin activity. (a) The Venn diagram shows the intersection of diabetes-related genes and ChEMBL-derived insulin activity-related genes in DisGeNET and Comparative Toxicogenomics Database. (b) Venn diagram displaying the intersection of C2, C8, and C10 marker genes with 93 genes. (c) The expression level of METAP2, PLAU, BRD4, NR3C1, HSP90AA1, CTSS, CTSB, and ADRB2 in C2, C8, and C10. (d) PPI network based on 88 genes. Red rhombus indicates the eight intersected genes associated with both T2DM and insulin activity.

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