Comprehensive Network Analysis Reveals the Targets and Potential Multitarget Drugs of Type 2 Diabetes Mellitus

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center">Score (kcal/mol)</td><td class="align_center">Hydrogen bond</td><td class="align_center">Hydrophobic bond</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">DB05494</td><td class="align_center">-8.0</td><td class="align_center">LYS26, TYR37, TYR89, CYS178, GLN280</td><td class="align_center">TRP86, PHE112, ILE198, TRP248, TYR251</td></tr><tr><td class="align_left">DB00629</td><td class="align_center">-6.5</td><td class="align_center">TYR37, GLU283</td><td class="align_center">TYR108, TRP86, TYR89</td></tr><tr><td class="align_left">DB01018</td><td class="align_center">-7.1</td><td class="align_center">TYR37, GLU283</td><td class="align_center">TRP86, TYR89, TYR108</td></tr><tr><td class="align_left">DB02594</td><td class="align_center">-5.8</td><td class="align_center">TYR37</td><td class="align_center">TRP86, TYR108</td></tr><tr><td class="align_left">DB00484</td><td class="align_center">-6.9</td><td class="align_center">—</td><td class="align_center">TRP86, TYR89, TYR108, THR167</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Docking results of CCR5 with five compounds.</div>

Oxidative Medicine and Cellular Longevity

tab2

Table 2

Table 2: Comprehensive Network Analysis Reveals the Targets and Potential Multitarget Drugs of Type 2 Diabetes Mellitus 