Electroacupuncture Attenuated Anxiety and Depression-Like Behavior via Inhibition of Hippocampal Inflammatory Response and Metabolic Disorders in TNBS-Induced IBD Rats

Table 2

The alterations in microbial composition at the level of the top 13 phyla, 30 families, and 30 genera of the group compared to the TNBS group.

Level	Regulation by EA
	Increased (X1 bacteria)	Decreased (X2 bacteria)	Further increased (X3 bacteria)	Further decreased (X4 bacteria)
Phylum	Firmicutes; Patescibacteria; Tenericutes; Planctomycetes	Bacteroidetes; Proteobacteria; Deferribacteres; Cyanobacteria; Fusobacteria	Epsilonbacteraeota; Verrucomicrobia; Acidobacteria	Actinobacteria
Family	Lactobacillaceae; Lachnospiraceae; Prevotellaceae; Erysipelotrichaceae; Peptostreptococcaceae; Acidaminococcaceae; Saccharimonadaceae; Family_XIII; Mollicutes_RF39_unclassified	Muribaculaceae; Christensenellaceae; Burkholderiaceae; Bacteroidaceae; Rikenellaceae; Desulfovibrionaceae; Bacteroidetes_unclassified; Enterobacteriaceae; Micrococcaceae; Tannerellaceae; Coriobacteriales_unclassified	Ruminococcaceae; Clostridiaceae; Streptococcaceae; Helicobacteraceae; Unclassified; Akkermansiaceae	Firmicutes_unclassified; Bifidobacteriaceae; Clostridiales_unclassified; Barnesiellaceae
Genus	Lactobacillus; Ruminococcaceae_UCG-014; Eubacterium]_coprostanoligenes_group; Ruminococcus_1; Lachnospiraceae_unclassified; Romboutsia; Muribaculum	Muribaculaceae_unclassified; Prevotellaceae_NK3B31_group; Ruminococcaceae_UCG-005; Christensenellaceae_R-7_group; Bacteroides; Alistipes	Phascolarctobacterium; Allobaculum; Roseburia; Ruminococcaceae_UCG-013; Streptococcus; Helicobacter; Blautia; Unclassified	Lachnospiraceae_NK4A136_group; Firmicutes_unclassified; Bifidobacterium; Fusicatenibacter; Eubacterium]_xylanophilum_group; Prevotellaceae_UCG-001; Clostridiales_unclassified; Burkholderia-Caballeronia-Paraburkholderia; Intestinimonas

Notes: With regard to the TNBS group, the concentration of X1 bacteria decreased while the concentration of X2 bacteria increased compared with the control group. EA treatment was able to restore the natural balance of these organisms (X1 bacteria increased; X2 bacteria decreased). With regard to the TNBS group, the concentration of X3 bacteria increased while the concentration of X4 bacteria decreased when compared to the control group. EA treatment exacerbated these changes by further elevating the concentration of X3 bacteria and lowering the concentration of X4 bacteria. ( by Kruskal-Wallis test).