Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism

Figure 1

HE staining in the images and assessment of RAC, MAD, and MLI revealed that hyperoxia exposure led to marked alveolar simplification. In addition, simvastatin treatment could attenuate lung morphological changes. (a) HE staining (light microscopy, ×100) of lung tissue slides from each group. Scale . (b–d) Semiquantitative pathology determination of RAC, MAD, and MLI in lung tissues. The values are ; , analyzed by two-way ANOVA with the Bonferroni post hoc test. and versus the normoxia group; and versus the hyperoxia group.

(a)

(b)

(c)

(d)