Glycyrrhizin Attenuates Hypoxic-Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway

Figure 1

Glycyrrhizin improves cortical neuronal loss after HIBD and OGD. (a) HE-stained coronal sections from each group. The arrow indicates shrunken neuronal nuclei and sparse neurons. (b) Immunofluorescence labeling of TUNEL and NeuN in the cerebral cortex 72 h after HI (). (c) The statistical analysis of NeuN (+) cell counts (). (d) Statistical analysis of TUNEL (+)/NeuN (+) cell counts (). (e) Representative immunofluorescence of nuclear staining in primary cortical neurons. (f, g) Cell counting and cell viability in vitro (). vs. the Con group; # vs. the HI group or OGD group.

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